Nicole DeHuff was born in Oklahoma. She began her acting studies at the prestigious Carnegie Mellon Acting Conservatory. Her first screen role was in the comedy hit Meet the Parents (2000), in which she co-starred with Robert De Niro and Ben Stiller.
Her character (Deborah Byrnes) was the sister whose wedding caused chaos for her family. She subsequently appeared in a guest capacity in such television programs as CSI: Miami (2002), Monk (2002) and The Practice (1997).
Nicole married in 2000 to Ari Palitz, but had no children. She passed away from pneumonia on 16 February 2005 in Los Angeles. She was 30 years old.
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